SAMe: The Accidental Pain Eraser

SAMe: The Accidental Pain Eraser

Summary: S-Adenosylmethionine (SAMe) is a compound found naturally in almost every tissue and fluid in the body.

A number of studies show that SAMe may reduce pain and inflammation in the joints – including in the spine (back pain). Researchers also believe it may promote cartilage repair.

In several studies (ranging in length from 1-3 months), SAMe was tested against NSAID drugs, such as ibuprofen and naproxen, in adults with hip, spine, or knee osteoarthritis. In those studies, SAMe was as effective as NSAIDs in relieving morning stiffness, reducing pain and swelling, improving range of motion, and increasing walking pace.

Studies also suggest SAMe has fewer side effects than NSAIDs (which can be dangerous, especially for seniors). Another study compared SAMe to celecoxib (Celebrex), a type of NSAID called a COX-2 inhibitor, and found that over time SAMe was as effective at relieving pain as the prescription drug.

“Sir, I don’t know what’s happening to me. I’m having the strangest side effect… my pain is almost gone!”

Happy tears flowed down Maria’s face… but her interviewers dropped their pens.

They were stunned.

This was Maria’s final interview in a cutting-edge clinical trial, taking place in Milan, Italy.

But the scientists didn’t know Maria had been suffering from excruciating arthritis for years. Or that the daily pain in her knees and hips had taken over her life.

In fact, they didn’t know she was diagnosed with osteoarthritis… because they never thought to ask.

After all, her pain had nothing to do with their experiment.

The Italian scientists were studying a natural compound called S-adenosyl-L-methionine (or SAMe for short) and its effects on depression in the brain.

But shortly after Maria left, more study subjects showed up for their interviews all reporting the same strange side-effect…

Disappearing joint pain.

The scientists looked at each other – and their eyes went wide.

They even wrote down “Marked improvement in joint disease” in their notes.

Had they accidentally discovered a natural arthritis pain cure… in a brain study?

SAMe: The Missing Link to a Life Without Pain?

They didn’t know it at the time, but this “accidental breakthrough” was huge.

The scientists had finally unlocked SAMe’s raw power… and later research confirmed their findings:

SAMe has access to a secret “language” between the brain and liver…

To switch off pain…

To repair and protect damaged cartilage…

And even tell arthritic joints to rebuild themselves and heal

And by using this special “language,” SAMe can be every bit as powerful as top NSAID drugs when it comes to beating pain and inflammation.

The only difference? SAMe is natural.

And it doesn’t have any of the dangerous or deadly side-effects that come with prescription drugs.

QUIZ: Your back pain never goes away until you address THIS

Harvard doctors reveal a direct link between excruciating back pain (or sciatica) and this little-known muscle. Can you guess what it is?

A. trapezius
B. piriformis
C. gastrocnemius/calves

You probably won’t get it right, even if you’re a total health nut.

The answer is counter-intuitive.

Click here to jump straight to the answer.

NSAIDs: Playing Russian Roulette with Your Health

If there’s one list of facts that gets me hopping mad, it’s the truth about NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).

They’re incredibly common and include prescription drugs like Celebrex and Vioxx, as well as over-the-counter drugs like aspirin, Aleve, and Advil, among many others.

And if you’ve over the age of 60, you probably think they’re a safe way to manage your arthritis pain.

But did you know…our own FDA admits they can be deadly for seniors.

Just listen to this…
According to some estimates, these drugs – which are prescribed more than 100 million times a year in the U.S….

Put more than 100,000 people in the hospital annually

Kill at least 16,000 Americans every year

Plus, most of these hospitalizations and deaths are in seniors… (Yes, the very folks who need pain relief most.)

Did you also know that just one single dose of an NSAID increases the risk of a stroke, heart attack, and gastrointestinal (GI) bleeding?

Not to mention other dangerous side effects like ulcers, liver and kidney dysfunction…

In fact, here are a few of the known side effects of NSAIDs:

    • Heart attacks
    • Stomach bleeding and perforation
    • High blood pressure (hypertension)
    • Congestive heart failure
    • Stomach and intestinal ulcers
    • Necrosis (cell death) in the kidneys
    • Stroke
    • Chronic kidney disease

Again, just to name a few…

But did your doctor ever mention that to you?

And in case you think over-the-counter medicine, like aspirin, Advil, Aleve, ibuprofen, and naproxen are all safer options… I’m afraid they could still be dangerous.

Here’s the smoking gun…

In 2018, the journal of Aging and Disease reported that folks over 65 – yes, the very people who need pain relief most – have a 400% greater risk of stomach bleeding with any type of NSAID.

And in 2015, FDA deputy director Dr. Judy Racoosin admitted NSAIDs are SO dangerous that “There is no period of use shown to be without risk.”

That’s why the FDA itself slapped a “black box warning” on every NSAID sold, warning of potential heart attacks and strokes.

In other words, it’s kind of like you’re playing Russian Roulette every single time you pop a pill.

With statistics like that, suddenly it makes sense why more than 100,000 people are hospitalized, and more than 16,000 people die every year, just from taking NSAIDs as directed.

But I’ll bet you’ll never see that on an aspirin commercial…

Instead, they have us thinking it’s A-OK to pop them every day like candy. And that’s what we do.

About 7 out of every 10 people 65 years or older use NSAIDs at least once per week.

And about half of those people use NSAIDs daily.

For the millions of seniors desperate to find pain relief, they’re willing to take the risk.

Maybe you’re even one of them?

But what if there were a different way? A safer, natural way to get the EXACT same pain relief…

But without the dangerous and even deadly side effects?

The Pain-Erasing Solution Already Inside You

Unlike manmade NSAIDs, SAMe is so natural, it’s already inside us – created in our brain and liver.

And it has a very important job too… well, more like 100 important jobs.

Because SAMe is found inside every living cell, and it’s responsible for over 100 different chemical reactions we need to survive.

But now, science has shown that for seniors suffering with osteoarthritis, SAMe could hold the key to a life with much less pain… better, unrestricted movement… and a happier, healthier outlook.

That’s not some unverified theory either.

SAMe has been shown to dramatically transform the lives of seniors in eight different clinical trials on more than 22,000 arthritis sufferers…

And in those studies, it’s been just as powerful of a painkiller as five different NSAIDs.

I’m talking about ibuprofen, naproxen, and even three prescription-level NSAIDs, like Celebrex… but without any of the dangerous side-effects.

Take a look at this double-blind study (considered the gold-standard of research) from the University of California, Irvine, where SAMe was tested head-to-head against prescription drug Celebrex on 56 patients with painful osteoarthritis in their knees.

In the study, both the arthritis patients and the researchers were in the dark about who got what. But eight weeks later… the results were crystal clear.

When it came to relieving arthritis pain…

IT WAS A DEAD HEAT TIE.

Both therapies worked really well.

In one measurement (“pain level today”), erasing almost half – a full 48% – of the subjects’ pain.

Yes, natural SAMe worked just as well as a prescription painkiller, and the patients enjoyed:

    • Better joint function
    • Less tenderness and swelling in their knees
    • Less pain while walking
    • Better moods and vitality, and
    • An easier time with their daily routines, like housework, getting in and out of a car, and even crouching

But there was one huge difference between the two groups.

The SAMe group did take a little longer at first to start showing pain relief… but, after stopping the treatment, only the SAMe group enjoyed lasting results – up to a full 56 days after the study had ended!

Still, researchers were skeptical… was this study just a fluke?

And could SAMe stop arthritis pain not just in the knees… but all over the body?

They needed an answer.

So seniors with painful arthritis in their knees, hips, and back pain from arthritis in their spine volunteered for a second double-blind study.

One group was given SAMe and the other the prescription NSAID Indomethacin…

And four weeks later, the answer was right in front of them.

Once again, SAMe had improved the seniors’:

Stiffness in the morning…

Pain while both resting and moving…

The grating feeling of bone-on-bone…

Swelling…

Bending…

And movement…

Just as well as the prescription.

Yes, when it came to reversing frustrating, even agonizing, arthritis symptoms… natural SAMe was every bit as powerful as a drug.

But there was another catch…

Because nearly 40% of the prescription group dealt with nasty side effects like vertigo, stomach pain, fatigue, nightmares, and even blood in their stool.

Compare them to the lucky SAMe group, where only two people experienced some mild nausea…

Which group would you rather be in?

The winner is clear: SAMe.

How Does SAMe Work So Well?

Here’s the thing… SAMe was first discovered back in 1952.

And in all that time, scientists are still trying to learn exactly HOW this natural compound works to relieve pain.

They believe it may play a role in reducing painful inflammation… or even that it has a direct pain-relieving (analgesic) effect.

And because SAMe is part of us, it works naturally WITH the body – instead of against it. It’s even been shown to go one step further and protect the GI system and liver from damage.

(No NSAID on Earth can do that.)

So SAMe is as potent as a prescription, but without the deadly side effects.

It’s clear… when it comes to safely fighting pain and inflammation, SAMe beats OTC and prescription NSAIDs at every turn.

But there’s still so much more it can do.

Restore Lost Cartilage and Rebuild Younger Joints

By now you’ve learned how SAMe provides lasting pain relief, reduces stiffness, and soothes swollen joints.

But SAMe does so much more.

In fact, it can help transform old, creaky joints into new, younger joints.

That could help you walk, play golf, go about your daily routine, and even dance easier — with dramatically better movement and function.

What’s SAMe’s secret? It’s been scientifically verified to help “jump-start” cartilage repair…

That means it’s triggering the body to build more of its own healthy, cushiony cartilage, helping fix the underlying cause of osteoarthritis – wherever it hurts most.

Both in-vitro and animal studies have shown that SAMe increases chondrocyte proteoglycan synthesis and proliferation.

That is quite a mouthful, but the results can be life-changing.

In layman’s terms, SAMe stimulates new cartilage production way down at the cellular level.

See, “chondrocytes” are a fancy name for cartilage cells. And low numbers of chondrocytes are a hallmark of osteoarthritis.

And as the number of cartilage cells fall over time, so do our joints’ defenses. And that leads to more wear and tear, more stiffness, and more suffering.

But a proven solution that can restore the number of cartilage cells lost over time means we could finally reverse the disease process itself.

And that’s where SAMe comes in…

SAMe naturally flips our internal cartilage creation switch from “OFF” to “ON”… sending a fresh burst of energy to “dead” knees, elbows, shoulders, and hips to help replenish young, healthy cartilage that’s been missing for years and make every arthritic joint work like new again.

Friend, this is HUGE news…

It’s been shown to help naturally RE-GROW lost cartilage.

Which means enjoying younger knees, hips, hands, and feet again.

But don’t take my word for it…

I scoured the web for more real folks – like you – who are in-the-know about SAMe… and are using it right now. (Please note: names have been changed for privacy.)

Does SAMe Really Work?

Just ask Hope S. from Franklin, IL who called SAMe a “miracle treatment.”

“I was diagnosed with osteoarthritis in my left hip 2 years ago and have dealt with pain every day. 3 weeks ago, I found SAMe and have been mostly pain-free since. It’s pure bliss... a miracle treatment for me!”

Hope S.

62-year-old Tara S. was concerned about taking prescription drugs for her knee pain:

“When I was diagnosed with osteoarthritis in my knee, I immediately started looking into natural help vs. prescription medication. I stumbled across SAMe and am pleased with results. After about 3 days my knee felt different... after about 9 months, I can function almost l00%. I would recommend trying this as natural help for arthritis – better than surgery and cheaper too!”

Tara S.

74-year-old Mary D. had arthritic hands that hurt so much she had to give up her beloved guitar… but now she’s enjoying the music again thanks to SAMe.

“I’m a guitarist and in my early 60’s I developed severe arthritis in my hands. After playing guitar for 50 years, it became excruciating. I quit playing, but I missed it terribly... After a couple of years not playing, I tried SAMe – and in a few weeks I noticed a reduction of the pain and I found I could play guitar a little for short periods. After several months, my hands were still somewhat stiff and I wasn’t able to play as smoothly and freely as when I was younger, but I could play enough to really enjoy the music again.”

Mary D.

Harriet B. (age 64) from Coral Springs, FL, said:

“My pain is 90% gone in less than a week! I still have a degenerative disc, but no pain!”

Harriet B.

Bill A. (age 54) from San Bruno, CA, reported that his entire life is better…

“Not only has my pain disappeared, my mood in general has improved, as has my libido. I feel 20 years younger!”

Bill A.

Betty L. has relied on SAMe for nearly 20 years. She said…

“I’m in my 80s now -- with practically NO pain. I will NEVER give up my SAMe!”

Betty L.

BONUS TIP: Is Knee Surgery $5,000 Worth of Useless?

Up until now, the mainstream party line has always been, “If you’ve started losing cartilage – the only thing you can do is wait for things to get bad enough, then get surgery.”

But what if arthroscopic knee surgeries are just $5,000 worth of USELESS?

Yes, despite being one of the most common and expensive knee procedures in the U.S., three different studies (dating as far back as 2002) show when it comes to cartilage repair, arthroscopies do not heal and do not repair.

In fact, they may even make knees MORE unstable… or speed up their degenerative collapse.

Again, this was verified by independent scientific researchers almost 20 years ago.

But where were the headlines? The urgent health warnings? Again, big business wins out.

The TRUE Cause of Arthritis… Low SAMe?

For decades, doctors have thought, “Osteoarthritis is brought on by a lifetime of wear and tear on your joints…”

But scientific researchers have made a shocking observation between low levels of SAMe and higher risk of osteoarthritis.

Just a coincidence? Or are low levels of SAMe the TRUE cause of arthritis?

Now, it’s important to note that this discovery is so groundbreaking, we still need more human studies for the mainstream to confirm it.

But a fascinating discovery between natural SAMe levels in the body and osteoarthritis risk has already been published in a preliminary study.

And we think they’re onto something BIG.

Another published study in International Journal of Clinical Chemistry looked at blood samples in children and found that young people naturally have higher levels of SAMe in their bodies.

But when the researchers looked at adult blood? Their levels of SAMe were so much lower.

Is this the reason why young joints are so flexible and pain-free?

Is it all controlled by SAMe?

Well, as we’ve already learned, SAMe has been clinically shown to beat arthritis pain, stiffness, and swelling as well as prescription NSAIDs.

And SAMe has been clinically shown to “jump start” the cartilage repair process… helping restore healthy cartilage for younger, smoother joints.

Could painful osteoarthritis be caused by a SAMe deficiency? If future studies agree… we already have the natural key to prevent, defeat, and even reverse the disease itself.

Plus, SAMe’s list of pain-fighting accolades goes way beyond arthritis… it’s been shown to fight fibromyalgia pain, pain from spinal cord damage, bursitis, and even migraines.

If you know a loved one suffering from one of these conditions, be sure to tell them to look into SAMe.

How To Boost SAMe Levels For Comfortable Joints

If low levels of SAMe are trapping your joints with agony, it’s time to free them from the pain.

It’s time to feel a dramatic change in the way you move… to restore your confidence… and to focus on what really matters in life… instead of the pain.

Boosting your own levels of SAMe couldn’t be easier.

SAMe is sold in dietary supplement form, and you won’t have to look far to find it.

Google “SAMe Supplement,” then click on the shopping tab to be shown the 5-star suppliers. You can also check Amazon and other major online retailers – just be sure to read the reviews before you buy.

Also, check your local GNC, Walmart, or other favorite health and wellness retailer.

SAMe tablets often come in 200 mg or 400 mg strength, so we recommend asking your doctor about the optimal dosage for your level of pain or about any potential interactions with your current medications.

Remember, one of the consensuses is that SAMe is safe, without any dangerous side-effects, but you should always talk to your doctor first before changing anything about your healthcare.

Sources

Davis, Abigail. “The Dangers of NSAIDs: Look Both Ways.” PubMed Central (PMC), 1 Apr. 2016, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809680/.

Najm, Wadie. “S-Adenosyl Methionine (SAMe) versus Celecoxib for the Treatment of Osteoarthritis Symptoms: A Double-Blind Cross-over Trial. [ISRCTN36233495] – PubMed.” PubMed, 1 Jan. 2004, https://pubmed.ncbi.nlm.nih.gov/15102339/.

S-adenosylmethionine article; https://www.mountsinai.org/health-library/supplement/s-adenosylmethionine

Kim J, Lee EY, Koh EM, et al. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis; an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Clin Ther. 2009;31(12):2860-72.